Acute Methiopropamine Intoxication After "Synthacaine" Consumption.
J Anal Toxicol
; 40(9): 758-760, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27474360
ABSTRACT
Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and incoherent speech following the use of "synthacaine" (a slang term derived from "synthetic" and "cocaine"). Toxicological screening for pharmaceuticals and drugs of abuse by liquid chromatography-diode-array detector, gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry (LC-MS-MS) detected MPA, which was subsequently quantified by a specific LC-MS-MS method. Of note, 13 h after presentation to the emergency department, the plasma concentration of MPA was 14 ng/mL. This case report confirms the toxicity of MPA and the need for toxicological analysis to confirm the substance actually ingested by users of new psychoactive substances.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Drogas Ilícitas
/
Transtornos Relacionados ao Uso de Substâncias
/
Metanfetamina
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Anal Toxicol
Ano de publicação:
2016
Tipo de documento:
Article