Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses.

Chow, Edwin Chiu Yuen; Talattof, Arjang; Tsakalozou, Eleftheria; Fan, Jianghong; Zhao, Liang; Zhang, Xinyuan

Chow, Edwin Chiu Yuen; Talattof, Arjang; Tsakalozou, Eleftheria; Fan, Jianghong; Zhao, Liang; Zhang, Xinyuan.

Afiliação

Chow EC; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.
Talattof A; , 10903 New Hampshire Ave., Bldg. 75, Room 4690, Silver Spring, Maryland, 20993, USA.
Tsakalozou E; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.
Fan J; , 10903 New Hampshire Ave., Bldg. 75, Room 4690, Silver Spring, Maryland, 20993, USA.
Zhao L; Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.
Zhang X; , 10903 New Hampshire Ave., Bldg. 75, Room 4690, Silver Spring, Maryland, 20993, USA.

AAPS J ; 18(6): 1500-1511, 2016 11.

Article em En | MEDLINE | ID: mdl-27520379

Assuntos

Excipientes/química; Modelos Teóricos; Administração Oral; Área Sob a Curva; Permeabilidade; Solubilidade

Palavras-chave

Biopharmaceutics Classification System (BCS); PBPK modeling; excipients; gastrointestinal transporters; oral drug absorption

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Excipientes / Modelos Teóricos Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: AAPS J Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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