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On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.
Cho, Hyejin; Du, Xinlin; Rizzi, James P; Liberzon, Ella; Chakraborty, Abhishek A; Gao, Wenhua; Carvo, Ingrid; Signoretti, Sabina; Bruick, Richard K; Josey, John A; Wallace, Eli M; Kaelin, William G.
Afiliação
  • Cho H; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Du X; Peloton Therapeutics, Inc., Dallas, Texas 75235, USA.
  • Rizzi JP; Peloton Therapeutics, Inc., Dallas, Texas 75235, USA.
  • Liberzon E; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Chakraborty AA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Gao W; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Carvo I; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Signoretti S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Bruick RK; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Josey JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wallace EM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.
  • Kaelin WG; Peloton Therapeutics, Inc., Dallas, Texas 75235, USA.
Nature ; 539(7627): 107-111, 2016 11 03.
Article em En | MEDLINE | ID: mdl-27595393
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Carcinoma de Células Renais / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Indanos / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Carcinoma de Células Renais / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Indanos / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos