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Chiral Separation of Cytotoxic Flavan Derivatives from Daphne giraldii.
Li, Fei-Fei; Sun, Qian; Wang, Di; Liu, Sen; Lin, Bin; Liu, Chun-Ting; Li, Ling-Zhi; Huang, Xiao-Xiao; Song, Shao-Jiang.
Afiliação
  • Li FF; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Sun Q; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Wang D; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Liu S; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Lin B; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Liu CT; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Li LZ; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Huang XX; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
  • Song SJ; Department of Natural Products Chemistry, ‡Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, and ⊥School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
J Nat Prod ; 79(9): 2236-42, 2016 09 23.
Article em En | MEDLINE | ID: mdl-27627130
ABSTRACT
Twelve new flavan derivatives including four pairs of enantiomers, daphnegiralins A1-A4 (1) and daphnegiralins B1-B4 (2), and two pairs of epimers, daphnegiralins C1/C2 (3) and daphnegiralins D1/D2 (4), were isolated from the stem bark and roots of Daphne giraldii. Their structures were elucidated using spectroscopic analyses, computational approaches, and chemical methods. Separation of the enantiomeric mixtures (1a, 1b, 2a, and 2b) was achieved using chiral HPLC. The compounds were evaluated against a small panel of human cancer cell lines, and 1b-2, 2a, and 2b were cytotoxic against Hep3B human hepatoma cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Polifenóis / Antineoplásicos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Polifenóis / Antineoplásicos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article