Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction.

Zakas, Philip M; Brown, Harrison C; Knight, Kristopher; Meeks, Shannon L; Spencer, H Trent; Gaucher, Eric A; Doering, Christopher B

Zakas, Philip M; Brown, Harrison C; Knight, Kristopher; Meeks, Shannon L; Spencer, H Trent; Gaucher, Eric A; Doering, Christopher B.

Afiliação

Zakas PM; Program in Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, Georgia, USA.
Brown HC; Program in Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, Georgia, USA.
Knight K; Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Meeks SL; Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Spencer HT; Program in Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, Georgia, USA.
Gaucher EA; Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Doering CB; School of Biology, Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA.

Nat Biotechnol ; 35(1): 35-37, 2017 Jan.

Article em En | MEDLINE | ID: mdl-27669166

Assuntos

Sequência Conservada/genética; Descoberta de Drogas/métodos; Sinergismo Farmacológico; Fator VIII/genética; Engenharia de Proteínas/métodos; Proteínas/genética; Fator VIII/uso terapêutico; Proteínas/uso terapêutico; Homologia de Sequência de Aminoácidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Engenharia de Proteínas / Proteínas / Sequência Conservada / Sinergismo Farmacológico / Descoberta de Drogas Tipo de estudo: Prognostic_studies Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google