Voltage-Gated Potassium Channel Antibodies in Slow-Progression Motor Neuron Disease.
Neurodegener Dis
; 17(1): 59-62, 2017.
Article
em En
| MEDLINE
| ID: mdl-27710962
ABSTRACT
BACKGROUND:
The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown.OBJECTIVE:
The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND).METHODS:
We compared 11 patients affected by slow-progression MND with 9 patients presenting typical progression illness. Sera were tested for VGKC-complex Abs by radioimmunoassay. The distribution of VGKC-complex Abs was analyzed with the Mann-Whitney U test.RESULTS:
The statistical analysis showed a significant difference between the mean values in the study and control groups. A case with long-survival MND harboring VGKC-complex Abs and treated with intravenous immunoglobulins is described.CONCLUSION:
Although VGKC-complex Abs are not likely to be pathogenic, these results could reflect the coexistence of an immunological activation in patients with slow disease progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Doença dos Neurônios Motores
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurodegener Dis
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Itália