Airflow limitation as a risk factor for low bone mineral density and hip fracture.
Eur Clin Respir J
; 3: 32214, 2016.
Article
em En
| MEDLINE
| ID: mdl-27733234
ABSTRACT
AIM:
To investigate whether airflow limitation is associated with bone mineral density (BMD) and risk of hip fractures.METHODS:
A community sample of 5,100 subjects 47-48 and 71-73 years old and living in Bergen was invited. Participants filled in questionnaires and performed a post-bronchodilator spirometry measuring forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). All attendants were invited to have a BMD measurement of the hip. During 10 years of follow-up, information on death was collected from the Norwegian Cause of Death Registry, and incident hip fractures were registered from regional hospital records of discharge diagnoses and surgical procedure codes.RESULTS:
The attendance rate was 69% (n=3,506). The prevalence of chronic obstructive pulmonary disease (COPD) (FEV1/FVC<0.7) was 9%. In multiple logistic regression, the lowest quartile of BMD versus the three upper was significantly predicted by FEV1/FVC<0.7 and FEV1% predicted (odds ratio [OR] 1.58, 95% confidence interval [CI] 1.11 to 2.25, and OR per increase of 10% 0.92, 95% CI 0.86 to 0.99, respectively). Hip fracture occurred in 126 (4%) participants. In a Cox regression analysis, FEV1% predicted was associated with a lowered risk of hip fracture (hazard ratio per increase of 10% 0.89, 95% CI 0.79 to 0.997).CONCLUSION:
Airflow limitation is positively associated with low BMD and risk of hip fracture in middle-aged and elderly.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Eur Clin Respir J
Ano de publicação:
2016
Tipo de documento:
Article