High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model.
Gastrointest Endosc
; 85(5): 1076-1085, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27751874
ABSTRACT
BACKGROUND AND AIMS:
Extensive excision of the esophageal mucosa by endoscopic submucosal dissection (ESD) frequently evokes a luminal stricture. This study aimed to determine the efficacy of a high-density collagen patch for the prevention of esophageal stricture in extensive ESD.METHODS:
Six pigs underwent circumferential esophageal ESD under general anesthesia. In 3 pigs, artificial ulcers were covered by 2 collagen patches. The other 3 pigs underwent circumferential ESD only.RESULTS:
The 2 collagen patches were settled onto the ulcer surface using a general endoscope and instruments. The collagen patch-treated group showed significantly better patency rates on both the oral and anal sides of the wound area compared with the control group at day 14. The mucosal re-epithelization ratio was significantly promoted, and the extent of mucosal inflammation and fibrosis was significantly decreased with the collagen patch treatment in the wound area. The frequency of cells positive α-smooth muscle actin was significantly reduced in the collagen patch-treated group compared with the control group.CONCLUSIONS:
We have established a high-density collagen device that can reduce the esophageal stricture associated with extensive ESD. This easy-to-handle device would be useful during superficial esophageal cancer treatment by ESD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Cicatrização
/
Colágeno
/
Esofagoscopia
/
Estenose Esofágica
/
Esôfago
/
Mucosa Esofágica
/
Ressecção Endoscópica de Mucosa
Limite:
Animals
Idioma:
En
Revista:
Gastrointest Endosc
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão