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Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring, Christopher; Antoine, Daniel J; Bonner, Frank; Crozier, Jonathan; Denning, Chris; Fontana, Robert J; Hanley, Neil A; Hay, David C; Ingelman-Sundberg, Magnus; Juhila, Satu; Kitteringham, Neil; Silva-Lima, Beatriz; Norris, Alan; Pridgeon, Chris; Ross, James A; Young, Rowena Sison; Tagle, Danilo; Tornesi, Belen; van de Water, Bob; Weaver, Richard J; Zhang, Fang; Park, B Kevin.
Afiliação
  • Goldring C; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Antoine DJ; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Bonner F; Stem Cells for Safer Medicines, London, UK.
  • Crozier J; European Partnership for Alternative Approaches to Animal Testing, Brussels, Belgium.
  • Denning C; Department of Stem Cell Biology, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Fontana RJ; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Hanley NA; Centre for Endocrinology & Diabetes, University of Manchester, and Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  • Hay DC; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
  • Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Juhila S; R&D, In Vitro Biology, Orion Pharma, Espoo, Finland.
  • Kitteringham N; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Silva-Lima B; Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
  • Norris A; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Pridgeon C; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Ross JA; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
  • Young RS; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Tagle D; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD.
  • Tornesi B; Abbvie Global Pharmaceutical Research and Development, North Chicago, IL.
  • van de Water B; Faculty of Science, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, University of Leiden, Leiden, The Netherlands.
  • Weaver RJ; Institut de Recherches Internationales Servier, Suresnes, France.
  • Zhang F; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Park BK; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Hepatology ; 65(2): 710-721, 2017 02.
Article em En | MEDLINE | ID: mdl-27775817
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Toxicidade / Hepatócitos / Células-Tronco Pluripotentes / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Hepatology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Toxicidade / Hepatócitos / Células-Tronco Pluripotentes / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Hepatology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido