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miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.
Serr, Isabelle; Fürst, Rainer W; Ott, Verena B; Scherm, Martin G; Nikolaev, Alexei; Gökmen, Füsun; Kälin, Stefanie; Zillmer, Stephanie; Bunk, Melanie; Weigmann, Benno; Kunschke, Nicole; Loretz, Brigitta; Lehr, Claus-Michael; Kirchner, Benedikt; Haase, Bettina; Pfaffl, Michael; Waisman, Ari; Willis, Richard A; Ziegler, Anette-G; Daniel, Carolin.
Afiliação
  • Serr I; Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany.
  • Fürst RW; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Klinikum rechts der Isar, Technische Universität München, 80939 Munich, Germany.
  • Ott VB; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Division of Metabolic Diseases, Technische Universität München, 85748 Munich, Germany.
  • Scherm MG; Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany.
  • Nikolaev A; Institute for Molecular Medicine, Universitätsmedizin der Johannes Gutenberg-Universität, 55131 Mainz, Germany.
  • Gökmen F; Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany.
  • Kälin S; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Division of Metabolic Diseases, Technische Universität München, 85748 Munich, Germany.
  • Zillmer S; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Klinikum rechts der Isar, Technische Universität München, 80939 Munich, Germany.
  • Bunk M; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Klinikum rechts der Isar, Technische Universität München, 80939 Munich, Germany.
  • Weigmann B; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, 91052 Erlangen, Germany.
  • Kunschke N; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, 66123 Saarbruecken, Germany.
  • Loretz B; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, 66123 Saarbruecken, Germany.
  • Lehr CM; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, 66123 Saarbruecken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbruecken, Germany.
  • Kirchner B; Physiology Weihenstephan, Technische Universität München, 85354 Freising, Germany.
  • Haase B; Genomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
  • Pfaffl M; Physiology Weihenstephan, Technische Universität München, 85354 Freising, Germany.
  • Waisman A; Institute for Molecular Medicine, Universitätsmedizin der Johannes Gutenberg-Universität, 55131 Mainz, Germany.
  • Willis RA; Emory Vaccine Center, NIH Tetramer Core Facility, Atlanta, GA 30322.
  • Ziegler AG; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Klinikum rechts der Isar, Technische Universität München, 80939 Munich, Germany.
  • Daniel C; Institute for Diabetes Research, Independent Young Investigator Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung, 85764 Munich, Germany; carolin.daniel@helmholtz-muenchen.de.
Proc Natl Acad Sci U S A ; 113(43): E6659-E6668, 2016 10 25.
Article em En | MEDLINE | ID: mdl-27791035
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoimunidade / Linfócitos T Auxiliares-Indutores / MicroRNAs / Diabetes Mellitus Tipo 1 / PTEN Fosfo-Hidrolase / Fatores de Transcrição Kruppel-Like Tipo de estudo: Prognostic_studies Limite: Adolescent / Animals / Child / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoimunidade / Linfócitos T Auxiliares-Indutores / MicroRNAs / Diabetes Mellitus Tipo 1 / PTEN Fosfo-Hidrolase / Fatores de Transcrição Kruppel-Like Tipo de estudo: Prognostic_studies Limite: Adolescent / Animals / Child / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha