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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
Telliez, Jean-Baptiste; Dowty, Martin E; Wang, Lu; Jussif, Jason; Lin, Tsung; Li, Li; Moy, Erick; Balbo, Paul; Li, Wei; Zhao, Yajuan; Crouse, Kimberly; Dickinson, Caitlyn; Symanowicz, Peter; Hegen, Martin; Banker, Mary Ellen; Vincent, Fabien; Unwalla, Ray; Liang, Sidney; Gilbert, Adam M; Brown, Matthew F; Hayward, Matthew; Montgomery, Justin; Yang, Xin; Bauman, Jonathan; Trujillo, John I; Casimiro-Garcia, Agustin; Vajdos, Felix F; Leung, Louis; Geoghegan, Kieran F; Quazi, Amira; Xuan, Dejun; Jones, Lyn; Hett, Erik; Wright, Katherine; Clark, James D; Thorarensen, Atli.
Afiliação
  • Telliez JB; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Dowty ME; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Wang L; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Jussif J; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Lin T; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Li L; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Moy E; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Balbo P; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Li W; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Zhao Y; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Crouse K; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Dickinson C; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Symanowicz P; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Hegen M; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Banker ME; Primary Pharmacology Group, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Vincent F; Primary Pharmacology Group, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Unwalla R; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Liang S; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Gilbert AM; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Brown MF; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Hayward M; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Montgomery J; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Yang X; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Bauman J; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Trujillo JI; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Casimiro-Garcia A; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Vajdos FF; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Leung L; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Geoghegan KF; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Quazi A; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Xuan D; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Jones L; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Hett E; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Wright K; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Clark JD; Inflammation and Immunology, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Thorarensen A; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
ACS Chem Biol ; 11(12): 3442-3451, 2016 12 16.
Article em En | MEDLINE | ID: mdl-27791347
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Pirimidinas / Pirróis / Inibidores de Proteínas Quinases / Encefalomielite Autoimune Experimental / Janus Quinase 3 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Pirimidinas / Pirróis / Inibidores de Proteínas Quinases / Encefalomielite Autoimune Experimental / Janus Quinase 3 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos