Polychlorinated biphenyls exposure-induced insulin resistance is mediated by lipid droplet enlargement through Fsp27.

Kim, Hye Young; Kwon, Woo Young; Kim, Yeon A; Oh, Yoo Jin; Yoo, Seung Hee; Lee, Mi Hwa; Bae, Ju Yong; Kim, Jong-Min; Yoo, Young Hyun

Kim, Hye Young; Kwon, Woo Young; Kim, Yeon A; Oh, Yoo Jin; Yoo, Seung Hee; Lee, Mi Hwa; Bae, Ju Yong; Kim, Jong-Min; Yoo, Young Hyun.

Afiliação

Kim HY; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Kwon WY; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Kim YA; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Oh YJ; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Yoo SH; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Lee MH; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Bae JY; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Kim JM; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea.
Yoo YH; Department of Anatomy and Cell Biology, Dong-A University College of Medicine, Dongdaeshin-dong 3-1, Seo-gu, Busan, 602-714, Republic of Korea. yhyoo@dau.ac.kr.

Arch Toxicol ; 91(6): 2353-2363, 2017 Jun.

Article em En | MEDLINE | ID: mdl-27837308

Assuntos

Adipócitos/efeitos dos fármacos; Resistência à Insulina; Gotículas Lipídicas/metabolismo; Bifenilos Policlorados/toxicidade; Proteínas/metabolismo; Células 3T3-L1; Adipócitos/metabolismo; Tecido Adiposo/efeitos dos fármacos; Tecido Adiposo/metabolismo; Animais; Glicemia/análise; Técnicas de Cultura de Células; Diferenciação Celular/efeitos dos fármacos; Tamanho Celular/efeitos dos fármacos; Insulina/farmacologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Proteínas/genética; RNA Interferente Pequeno/genética

Palavras-chave

Fat-specific protein 27; Insulin resistance; Lipid droplet enlargement; Polychlorinated biphenyls

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Proteínas / Bifenilos Policlorados / Adipócitos / Gotículas Lipídicas Limite: Animals Idioma: En Revista: Arch Toxicol Ano de publicação: 2017 Tipo de documento: Article

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