Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice.

Dai, Qinggang; Xie, Furong; Han, Yujiao; Ma, Xuhui; Zhou, Siru; Jiang, Lingyong; Zou, Weiguo; Wang, Jun

Dai, Qinggang; Xie, Furong; Han, Yujiao; Ma, Xuhui; Zhou, Siru; Jiang, Lingyong; Zou, Weiguo; Wang, Jun.

Afiliação

Dai Q; From the Departments of Pediatric Dentistry.
Xie F; the State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Han Y; From the Departments of Pediatric Dentistry.
Ma X; the State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Zhou S; Oral and Maxillofacial Head and Neck Oncology, and.
Jiang L; Center of Craniofacial Orthodontics, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011 and.
Zou W; Center of Craniofacial Orthodontics, Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011 and jly117@sina.com.
Wang J; the State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China zouwg94@sibcb.ac.cn.

J Biol Chem ; 292(1): 196-204, 2017 Jan 06.

Article em En | MEDLINE | ID: mdl-27879318

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores; Osso e Ossos/patologia; Diferenciação Celular; Complexos Multiproteicos/antagonistas & inibidores; Osteoclastos/patologia; Osteogênese/fisiologia; Serina-Treonina Quinases TOR/antagonistas & inibidores; Proteínas Adaptadoras de Transdução de Sinal/fisiologia; Animais; Densidade Óssea; Osso e Ossos/metabolismo; Células Cultivadas; Macrófagos/metabolismo; Macrófagos/patologia; Masculino; Alvo Mecanístico do Complexo 1 de Rapamicina; Camundongos; Camundongos Knockout; Complexos Multiproteicos/genética; Complexos Multiproteicos/metabolismo; Osteoclastos/metabolismo; Fosforilação; Proteína Regulatória Associada a mTOR; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

S6 kinase; bone; cell differentiation; mTOR complex (mTORC); osteoclast; osteoporosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Osteogênese / Osso e Ossos / Diferenciação Celular / Complexos Multiproteicos / Proteínas Adaptadoras de Transdução de Sinal / Serina-Treonina Quinases TOR Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article

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