Rats can acquire conditional fear of faint light leaking through the acrylic resin used to mount fiber optic cannulas.
Learn Mem
; 23(12): 684-688, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27918272
ABSTRACT
Rodents are exquisitely sensitive to light and optogenetic behavioral experiments routinely introduce light-delivery materials into experimental situations, which raises the possibility that light could leak and influence behavioral performance. We examined whether rats respond to a faint diffusion of light, termed caplight, which emanated through the translucent dental acrylic resin used to affix deep-brain optical cannulas in place. Although rats did not display significant changes in locomotion or rearing to caplight in a darkened open field, they did acquire conditional fear via caplight-footshock pairings. These findings highlight the potential confounding influence of extraneous light emanating from light-delivery materials during optogenetic analyses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resinas Acrílicas
/
Cateteres de Demora
/
Fibras Ópticas
/
Medo
/
Optogenética
/
Luz
Limite:
Animals
Idioma:
En
Revista:
Learn Mem
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França