Skin autofluorescence, a non-invasive marker of advanced glycation end products: clinical relevance and limitations.
Postgrad Med J
; 93(1099): 289-294, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28143896
ABSTRACT
Advanced glycation end products (AGEs) are protein-bound compounds derived from glycaemic and oxidative stress that contain fluorescent properties, which can be non-invasively measured as skin autofluorescence (SAF) by the AGE Reader. SAF has been demonstrated to be a biomarker of cumulative skin AGEs and potentially may be a better predictor for the development of chronic complications and mortality in diabetes than glycated haemoglobin A1c. However, there are several confounding factors that should be assessed prior to its broader application these include presence of other fluorescent compounds in the skin that might be measured (eg, fluorophores), skin pigmentation and use of skin creams. The aim of this article is to provide a theoretical background of this newly developed method, evaluate its clinical relevance and discuss the potential confounding factors that need further analysis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Biomarcadores
/
Produtos Finais de Glicação Avançada
/
Diabetes Mellitus
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Postgrad Med J
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido