Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression.

Guo, Yue; Tang, Chen-Yi; Man, Xiao-Fei; Tang, Hao-Neng; Tang, Jun; Zhou, Ci-La; Tan, Shu-Wen; Wang, Min; Feng, Yun-Zhi; Zhou, Hou-De

Guo, Yue; Tang, Chen-Yi; Man, Xiao-Fei; Tang, Hao-Neng; Tang, Jun; Zhou, Ci-La; Tan, Shu-Wen; Wang, Min; Feng, Yun-Zhi; Zhou, Hou-De.

Afiliação

Guo Y; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Tang CY; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Man XF; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Tang HN; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Tang J; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Zhou CL; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Tan SW; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Wang M; Department of Metabolism & Endocrinology, Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Feng YZ; Department of Stomatology, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.
Zhou HD; Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, ChangSha, Hunan, China.

Dev Growth Differ ; 59(2): 94-103, 2017 Feb.

Article em En | MEDLINE | ID: mdl-28211947

Assuntos

Autoantígenos/metabolismo; Diferenciação Celular/efeitos dos fármacos; Colágeno Tipo I/biossíntese; Fator de Crescimento Insulin-Like I/farmacologia; Osteogênese/efeitos dos fármacos; Ribonucleoproteínas/metabolismo; Fosfatase Alcalina/metabolismo; Animais; Animais Recém-Nascidos; Autoantígenos/genética; Western Blotting; Diferenciação Celular/genética; Células Cultivadas; Colágeno Tipo I/genética; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; Relação Dose-Resposta a Droga; Expressão Gênica/efeitos dos fármacos; Camundongos Endogâmicos C57BL; Osteoblastos/citologia; Osteoblastos/efeitos dos fármacos; Osteoblastos/metabolismo; Osteocalcina/metabolismo; Osteogênese/genética; Ligação Proteica; Interferência de RNA; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Ribonucleoproteínas/genética; Fatores de Tempo; Antígeno SS-B

Palavras-chave

COL1A2; La ribonucleoprotein domain family member 6; insulin-like growth factor 1; osteoblast; osteogenic differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Ribonucleoproteínas / Autoantígenos / Fator de Crescimento Insulin-Like I / Diferenciação Celular / Colágeno Tipo I Limite: Animals Idioma: En Revista: Dev Growth Differ Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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