TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation.

Park, Seolhee; Shin, Hyeon-Jun; Shah, Masaud; Cho, Hey-Young; Anwar, Muhammad Ayaz; Achek, Asma; Kwon, Hyuk-Kwon; Lee, Byugsung; Yoo, Tae Hyeon; Choi, Sangdun

TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation.

Park, Seolhee; Shin, Hyeon-Jun; Shah, Masaud; Cho, Hey-Young; Anwar, Muhammad Ayaz; Achek, Asma; Kwon, Hyuk-Kwon; Lee, Byugsung; Yoo, Tae Hyeon; Choi, Sangdun.

Afiliação

Park S; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Shin HJ; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Shah M; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Cho HY; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Anwar MA; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Achek A; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Kwon HK; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Lee B; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Yoo TH; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea.
Choi S; Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea. Electronic address: sangdunchoi@ajou.ac.kr.

Biomaterials ; 126: 49-60, 2017 05.

Article em En | MEDLINE | ID: mdl-28254693

Assuntos

Imunidade; Antígeno 96 de Linfócito/metabolismo; Peptídeos/farmacologia; Receptor 4 Toll-Like/metabolismo; Animais; Técnicas de Visualização da Superfície Celular; Simulação por Computador; Humanos; Leucócitos Mononucleares/metabolismo; Ligantes; Lipopolissacarídeos; Camundongos; Camundongos Endogâmicos C57BL; Proteínas Quinases Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Células RAW 264.7; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Biopanning; In silico; Peptide drug; Phage display; Proinflammatory cytokine; Toll-like receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Antígeno 96 de Linfócito / Receptor 4 Toll-Like / Imunidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biomaterials Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Coréia do Sul

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