Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments.

Wu, Ren-Huang; Tsai, Ming-Han; Tsai, Kuen-Nan; Tian, Jia Ni; Wu, Jian-Sung; Wu, Su-Ying; Chern, Jyh-Haur; Chen, Chun-Hong; Yueh, Andrew

Wu, Ren-Huang; Tsai, Ming-Han; Tsai, Kuen-Nan; Tian, Jia Ni; Wu, Jian-Sung; Wu, Su-Ying; Chern, Jyh-Haur; Chen, Chun-Hong; Yueh, Andrew.

Afiliação

Wu RH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Tsai MH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Tsai KN; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Tian JN; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Wu JS; Department of Life Sciences, National Central University, Jhongli, Taiwan, Republic of China.
Wu SY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Chern JH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Chen CH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Yueh A; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan, Republic of China chunhong@nhri.org.tw andrewyueh@nhri.org.tw.

J Virol ; 91(12)2017 06 15.

Article em En | MEDLINE | ID: mdl-28381578

Assuntos

Efeito Citopatogênico Viral; Vírus da Dengue/genética; Mutagênese; Proteínas não Estruturais Virais/genética; Proteínas não Estruturais Virais/metabolismo; Alanina/metabolismo; Substituição de Aminoácidos; Proliferação de Células/genética; Vírus da Dengue/química; Vírus da Dengue/fisiologia; Células HEK293; Humanos; L-Lactato Desidrogenase/metabolismo; Leucina/genética; Mutação; Fenilalanina/genética; RNA Viral/metabolismo; Análise de Sequência; Proteínas não Estruturais Virais/química; Montagem de Vírus; Replicação Viral/genética

Palavras-chave

RNA replication; cytopathic effect; dengue virus; intermolecular interaction; scanning mutagenesis; transmembrane segment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Proteínas não Estruturais Virais / Efeito Citopatogênico Viral / Vírus da Dengue Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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