Mycobacterium tuberculosis lysine-É-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors.

Reshma, Rudraraju Srilakshmi; Jeankumar, Variam Ullas; Kapoor, Nidhi; Saxena, Shalini; Bobesh, Karyakulam Andrews; Vachaspathy, Astakala Rishi; Kolattukudy, Pappachan E; Sriram, Dharmarajan

Mycobacterium tuberculosis lysine-É-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors.

Reshma, Rudraraju Srilakshmi; Jeankumar, Variam Ullas; Kapoor, Nidhi; Saxena, Shalini; Bobesh, Karyakulam Andrews; Vachaspathy, Astakala Rishi; Kolattukudy, Pappachan E; Sriram, Dharmarajan.

Afiliação

Reshma RS; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Jeankumar VU; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Kapoor N; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Saxena S; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Bobesh KA; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Vachaspathy AR; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Kolattukudy PE; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Sriram D; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India. Electronic address: dsriram@hyderabad.bits-pilani.ac.in.

Bioorg Med Chem ; 25(10): 2761-2771, 2017 05 15.

Article em En | MEDLINE | ID: mdl-28389113

Assuntos

Antituberculosos/química; Proteínas de Bactérias/antagonistas & inibidores; Benzotiazóis/química; Inibidores Enzimáticos/química; Mycobacterium tuberculosis/metabolismo; Transaminases/antagonistas & inibidores; Antituberculosos/metabolismo; Antituberculosos/farmacologia; Proteínas de Bactérias/metabolismo; Benzotiazóis/metabolismo; Benzotiazóis/farmacologia; Sítios de Ligação; Domínio Catalítico; Desenho de Fármacos; Inibidores Enzimáticos/metabolismo; Inibidores Enzimáticos/farmacologia; Simulação de Acoplamento Molecular; Mycobacterium tuberculosis/efeitos dos fármacos; Relação Estrutura-Atividade; Transaminases/metabolismo

Palavras-chave

3D granuloma model; Benzothiazole derivatives; Dormancy; Lysine-É amino transferase; Mycobacterium tuberculosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Inibidores Enzimáticos / Benzotiazóis / Transaminases / Mycobacterium tuberculosis / Antituberculosos Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia

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