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Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver.
Andersen, Melvin E; Black, Michael B; Campbell, Jerry L; Pendse, Salil N; Clewell, Harvey J; Pottenger, Lynn H; Bus, James S; Dodd, Darol E; Kemp, Daniel C; McMullen, Patrick D.
Afiliação
  • Andersen ME; ScitoVation LLC, Six Davis Drive, PO Box 110566, Research Triangle Park, NC 27709-5566, United States.
  • Black MB; ScitoVation LLC, Six Davis Drive, PO Box 110566, Research Triangle Park, NC 27709-5566, United States. Electronic address: mblack@scitovation.com.
  • Campbell JL; Ramboll-Enviro, Inc., Six Davis Drive, PO Box 13441, Research Triangle Park, NC 27709, United States.
  • Pendse SN; ScitoVation LLC, Six Davis Drive, PO Box 110566, Research Triangle Park, NC 27709-5566, United States.
  • Clewell HJ; ScitoVation LLC, Six Davis Drive, PO Box 110566, Research Triangle Park, NC 27709-5566, United States.
  • Pottenger LH; Olin Corporation, 100 Larkin Center, Midland, MI 48674, United States.
  • Bus JS; Exponent, Inc., 5806 Woodberry Drive, Midland, MI 48640, United States.
  • Dodd DE; Charles River, 640 N. Elizabeth St., Spencerville, OH 45887, United States.
  • Kemp DC; Quintiles, 4820 Emperor Blvd., Durham, NC 27703, United States.
  • McMullen PD; ScitoVation LLC, Six Davis Drive, PO Box 110566, Research Triangle Park, NC 27709-5566, United States.
Toxicol Appl Pharmacol ; 332: 149-158, 2017 10 01.
Article em En | MEDLINE | ID: mdl-28392392
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Transcriptoma / Fígado / Pulmão / Hipóxia / Cloreto de Metileno Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Transcriptoma / Fígado / Pulmão / Hipóxia / Cloreto de Metileno Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos