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Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.
Sahm, Felix; Toprak, Umut H; Hübschmann, Daniel; Kleinheinz, Kortine; Buchhalter, Ivo; Sill, Martin; Stichel, Damian; Schick, Matthias; Bewerunge-Hudler, Melanie; Schrimpf, Daniel; Zadeh, Gelareh; Aldape, Ken; Herold-Mende, Christel; Beck, Katja; Staszewski, Ori; Prinz, Marco; Harosh, Carmit Ben; Eils, Roland; Sturm, Dominik; Jones, David T W; Pfister, Stefan M; Paulus, Werner; Ram, Zvi; Schlesner, Matthias; Grossman, Rachel; von Deimling, Andreas.
Afiliação
  • Sahm F; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
  • Toprak UH; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
  • Hübschmann D; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kleinheinz K; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Buchhalter I; Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.
  • Sill M; Department of Pediatric Immunology, Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany.
  • Stichel D; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schick M; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Bewerunge-Hudler M; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schrimpf D; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Zadeh G; Genomics and Proteomics Core Facility, Microarray Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Aldape K; Genomics and Proteomics Core Facility, Microarray Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Herold-Mende C; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Beck K; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Staszewski O; McFeeters-Hamilton Centre for Neuro-oncology, Princess Margaret Cancer Centre, Toronto, Canada.
  • Prinz M; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada.
  • Harosh CB; McFeeters-Hamilton Centre for Neuro-oncology, Princess Margaret Cancer Centre, Toronto, Canada.
  • Eils R; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
  • Sturm D; Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
  • Jones DTW; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Pfister SM; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Paulus W; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Ram Z; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
  • Schlesner M; Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
  • Grossman R; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • von Deimling A; Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.
Acta Neuropathol ; 134(1): 155-158, 2017 07.
Article em En | MEDLINE | ID: mdl-28474103
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurofibromina 2 / Neoplasias Meníngeas / Meningioma / Mutação / Neoplasias Induzidas por Radiação Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurofibromina 2 / Neoplasias Meníngeas / Meningioma / Mutação / Neoplasias Induzidas por Radiação Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha