Paracrine release of IL-2 and anti-CTLA-4 enhances the ability of artificial polymer antigen-presenting cells to expand antigen-specific T cells and inhibit tumor growth in a mouse model.

Zhang, Lei; Wang, Limin; Shahzad, Khawar Ali; Xu, Tao; Wan, Xin; Pei, Weiya; Shen, Chuanlai

Zhang, Lei; Wang, Limin; Shahzad, Khawar Ali; Xu, Tao; Wan, Xin; Pei, Weiya; Shen, Chuanlai.

Afiliação

Zhang L; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China.
Wang L; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China.
Shahzad KA; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China.
Xu T; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China.
Wan X; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China.
Pei W; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China.
Shen C; Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, Jiangsu, People's Republic of China. chuanlaishen@seu.edu.cn.

Cancer Immunol Immunother ; 66(9): 1229-1241, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28501941

Assuntos

Células Apresentadoras de Antígenos/imunologia; Antígeno CTLA-4/antagonistas & inibidores; Interleucina-2/metabolismo; Animais; Modelos Animais de Doenças; Feminino; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Comunicação Parácrina

Palavras-chave

Active immunotherapy; Anti-CTLA-4; Artificial antigen-presenting cells; IL-2; PLGA-MPs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-2 / Antígeno CTLA-4 / Células Apresentadoras de Antígenos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2017 Tipo de documento: Article

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