An evolving function of DNA-containing exosomes in chemotherapy-induced immune response.
Cell Res
; 27(6): 722-723, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28524163
ABSTRACT
Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Neoplasias Colorretais
/
Exossomos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos