Combining properties of different classes of PI3K&#945; inhibitors to understand the molecular features that confer selectivity.

Gong, Grace Q; Kendall, Jackie D; Dickson, James M J; Rewcastle, Gordon W; Buchanan, Christina M; Denny, William A; Shepherd, Peter R; Flanagan, Jack U

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

Gong, Grace Q; Kendall, Jackie D; Dickson, James M J; Rewcastle, Gordon W; Buchanan, Christina M; Denny, William A; Shepherd, Peter R; Flanagan, Jack U.

Afiliação

Gong GQ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.
Kendall JD; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
Dickson JMJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
Rewcastle GW; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Buchanan CM; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
Denny WA; School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
Shepherd PR; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
Flanagan JU; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.

Biochem J ; 474(13): 2261-2276, 2017 06 26.

Article em En | MEDLINE | ID: mdl-28526744

Assuntos

Desenho de Fármacos; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Inibidores de Fosfoinositídeo-3 Quinase; Antineoplásicos/química; Antineoplásicos/farmacologia; Domínio Catalítico; Proliferação de Células/efeitos dos fármacos; Classe I de Fosfatidilinositol 3-Quinases; Humanos; Ligantes; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Neoplasias/tratamento farmacológico; Neoplasias/enzimologia; Neoplasias/patologia; Ligação Proteica; Conformação Proteica

Palavras-chave

drug discovery and design; medicinal chemistry; molecular docking; phosphoinositide 3-kinase; signalling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores Enzimáticos / Inibidores de Fosfoinositídeo-3 Quinase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Nova Zelândia

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