Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor &#945;/Î´ (PPAR&#945;/Î´) dual agonists.

Shioi, Ryuta; Okazaki, Shogo; Noguchi-Yachide, Tomomi; Ishikawa, Minoru; Makishima, Makoto; Hashimoto, Yuichi; Yamaguchi, Takao

Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/Î´ (PPARα/Î´) dual agonists.

Shioi, Ryuta; Okazaki, Shogo; Noguchi-Yachide, Tomomi; Ishikawa, Minoru; Makishima, Makoto; Hashimoto, Yuichi; Yamaguchi, Takao.

Afiliação

Shioi R; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Okazaki S; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Noguchi-Yachide T; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Ishikawa M; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Makishima M; School of Medicine, Nihon University, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
Hashimoto Y; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Yamaguchi T; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: yamaguchi@iam.u-tokyo.ac.jp.

Bioorg Med Chem Lett ; 27(14): 3131-3134, 2017 07 15.

Article em En | MEDLINE | ID: mdl-28539218

Assuntos

PPAR alfa/agonistas; PPAR delta/agonistas; Acetamidas/síntese química; Acetamidas/química; Acetamidas/metabolismo; Sítios de Ligação; Genes Reporter; Células HEK293; Humanos; Ligantes; PPAR alfa/metabolismo; PPAR delta/metabolismo; Ligação Proteica; Estereoisomerismo; Tiazolidinedionas/química

Palavras-chave

Hybrid molecule; Non-carboxylic acid; Non-thiazolidinedione; PPAR agonist; Peroxisome proliferator-activated receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: PPAR alfa / PPAR delta Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão

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