[Modelling of phosphorus transfers during haemodialysis]. / Modélisation des transferts de phosphore pendant l'hémodialyse.
Nephrol Ther
; 13 Suppl 1: S89-S93, 2017 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-28577749
ABSTRACT
Chronic kidney disease causes hyperphosphatemia, which is associated with increased cardiovascular risk and mortality. In patients with end-stage renal disease, haemodialysis allows the control of hyperphosphatemia. During a 4-h haemodialysis session, between 600 and 700mg of phosphate are extracted from the plasma, whereas the latter contains only 90mg of inorganic phosphate. The precise origin of phosphates remains unknown. The modelling of phosphorus transfers allows to predict the outcome after changes in dialysis prescription (duration, frequency) with simple two-compartment models and to describe the transfers between the different body compartments with more complex models. Work using 31P nuclear magnetic resonance spectroscopy performed in animals showed an increase in intracellular phosphate concentration and a decrease in intracellular ATP during a haemodialysis session suggesting an intracellular origin of phosphates.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fósforo
/
Diálise Renal
/
Insuficiência Renal Crônica
/
Hiperfosfatemia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Nephrol Ther
Assunto da revista:
NEFROLOGIA
/
TERAPEUTICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França