Solar insolation in springtime influences age of onset of bipolar I disorder.
Acta Psychiatr Scand
; 136(6): 571-582, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28722128
ABSTRACT
OBJECTIVE:
To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.METHOD:
Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density.RESULTS:
There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001).CONCLUSION:
A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estações do Ano
/
Transtorno Bipolar
/
Internacionalidade
/
Radiação Eletromagnética
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
/
America do norte
/
America do sul
/
Asia
/
Europa
/
Oceania
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha