Users' guide to the surgical literature: how to assess an article using surrogate end points.
Can J Surg
; 60(4): 280-287, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28730989
ABSTRACT
SUMMARY:
Phase 3 randomized controlled trials are the widely accepted gold standard through which treatment decisions are made, as they assess the efficacy of a novel treatment against the control on the relevant patient population. The effectiveness of the novel treatment should be derived by measuring patient-important outcomes; however, to accurately assess these outcomes, clinical trials often require extensive patient follow-up and large sample sizes that can incur substantial expense. For this reason, investigators substitute surrogate end points to reduce the sample size and duration of a trial, ultimately reducing cost. The purpose of this article is to help surgeons appraise the surgical literature that use surrogate end points for patient-important outcomes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Procedimentos Cirúrgicos Operatórios
/
Bibliografias como Assunto
/
Biomarcadores
/
Avaliação de Resultados em Cuidados de Saúde
/
Guias como Assunto
/
Ensaios Clínicos Fase III como Assunto
Tipo de estudo:
Clinical_trials
/
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Can J Surg
Ano de publicação:
2017
Tipo de documento:
Article