Clinical significance of farnesoid X receptor expression in thyroid neoplasia.
Future Oncol
; 13(20): 1785-1792, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28762281
ABSTRACT
AIM:
To evaluate the clinical significance of farnesoid X receptor (FXR) in thyroid neoplasia. PATIENTS &METHODS:
FXR expression was assessed immunohistochemically on 88 thyroid neoplastic tissues (benign = 44, malignant = 44).RESULTS:
Enhanced FXR was more frequently observed in papillary carcinomas compared with hyperplastic nodules (p = 0.0489). In malignant lesions, elevated FXR was associated with capsular (p = 0.0004) and vascular invasion (p = 0.0056) and increased follicular cells' proliferative rate (p < 0.0001). Elevated FXR expression was also associated with larger tumor size (p = 0.0086), presence of lymph node metastases (p = 0.0239) and lymphatic invasion (p = 0.0086) and increased recurrence rate risk (p = 0.0239).CONCLUSION:
FXR may be associated with tumor aggressiveness that affects patients' survival in thyroid neoplasia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Biomarcadores Tumorais
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Receptores Citoplasmáticos e Nucleares
Limite:
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Grécia