Antitumor evaluation and 3D-QSAR studies of a new series of the spiropyrroloquinoline isoindolinone/aza-isoindolinone derivatives by comparative molecular field analysis (CoMFA).

Sadeghzadeh, Masoud; Salahinejad, Maryam; Zarezadeh, Nahid; Ghandi, Mehdi; Baghery, Maryam Keshavarz

Sadeghzadeh, Masoud; Salahinejad, Maryam; Zarezadeh, Nahid; Ghandi, Mehdi; Baghery, Maryam Keshavarz.

Afiliação

Sadeghzadeh M; Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, P.O. Box 11365-3486, Tehran, Iran. msadeghzadeh@aeoi.org.ir.
Salahinejad M; Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, P.O. Box 11365-3486, Tehran, Iran.
Zarezadeh N; School of Chemistry, College of Science, University of Tehran, P.O. Box 14155 6455, Tehran, Iran.
Ghandi M; School of Chemistry, College of Science, University of Tehran, P.O. Box 14155 6455, Tehran, Iran.
Baghery MK; Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, P.O. Box 11365-3486, Tehran, Iran.

Mol Divers ; 21(4): 821-830, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28836075

Assuntos

Indóis/química; Indóis/farmacologia; Modelos Moleculares; Relação Quantitativa Estrutura-Atividade; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Células MCF-7; Conformação Molecular

Palavras-chave

Antitumor agent; Breast cancer cell lines; Comparative molecular field analysis (CoMFA); Spiropyrroloquinoline aza-isoindolinone; Spiropyrroloquinoline isoindolinone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Moleculares / Relação Quantitativa Estrutura-Atividade / Indóis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Divers Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Irã

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