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In vitro activity of 1H-phenalen-1-one derivatives against Acanthamoeba castellanii Neff and their mechanisms of cell death.
López-Arencibia, Atteneri; Reyes-Batlle, María; Freijo, Mónica Blanco; McNaughton-Smith, Grant; Martín-Rodríguez, Patricia; Fernández-Pérez, Leandro; Sifaoui, Ines; Wagner, Carolina; García-Méndez, Ana B; Liendo, Aitor Rizo; Bethencourt-Estrella, Carlos J; Abad-Grillo, Teresa; Piñero, José E; Lorenzo-Morales, Jacob.
Afiliação
  • López-Arencibia A; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain. Electronic address: atlopez@ull.edu.es.
  • Reyes-Batlle M; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
  • Freijo MB; Instituto Universitario de Bio-Orgánica 'Antonio González', Departamento de Química Orgánica, Universidad de La Laguna, Avda. Fco. Sánchez 2, 38206, La Laguna, Tenerife, Spain.
  • McNaughton-Smith G; Centro Atlántico del Medicamento S.A (CEAMED S.A.), PCTT, La Laguna, Tenerife, Spain.
  • Martín-Rodríguez P; Centro Atlántico del Medicamento S.A (CEAMED S.A.), PCTT, La Laguna, Tenerife, Spain; Department of Clinical Sciences, Molecular and Translational Endocrinology Group, University of Las Palmas de GC-Cancer Research Institute of the Canary Islands (ICIC), Spain.
  • Fernández-Pérez L; Centro Atlántico del Medicamento S.A (CEAMED S.A.), PCTT, La Laguna, Tenerife, Spain; Department of Clinical Sciences, Molecular and Translational Endocrinology Group, University of Las Palmas de GC-Cancer Research Institute of the Canary Islands (ICIC), Spain.
  • Sifaoui I; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
  • Wagner C; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain; Cátedra de Parasitología, Escuela de Bioanálisis, Facultad de Medicina, Universidad Central de Venezuela
  • García-Méndez AB; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
  • Liendo AR; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
  • Bethencourt-Estrella CJ; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
  • Abad-Grillo T; Instituto Universitario de Bio-Orgánica 'Antonio González', Departamento de Química Orgánica, Universidad de La Laguna, Avda. Fco. Sánchez 2, 38206, La Laguna, Tenerife, Spain.
  • Piñero JE; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
  • Lorenzo-Morales J; University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
Exp Parasitol ; 183: 218-223, 2017 Dec.
Article em En | MEDLINE | ID: mdl-28916457
ABSTRACT
Acanthamoeba is an opportunistic pathogen which is the causal agent of a sight-threatening ulceration of the cornea known as Acanthamoeba keratitis (AK) and, more rarely, an infection of the central nervous system called "granulomatous amoebic encephalitis" (GAE). The symptoms of AK are non-specific, and so it can be misdiagnosed as a viral, bacterial, or fungal keratitis. Furthermore, current therapeutic measures against AK are arduous, and show limited efficacy against the cyst stage of Acanthamoeba. 1H-Phenalen-1-one (PH) containing compounds have been isolated from plants and fungi, where they play a crucial role in the defense mechanism of plants. Natural as well as synthetic PHs exhibit a diverse range of biological activities against fungi, protozoan parasites or human cancer cells. New synthetic PHs have been tested in this study and they show a potential activity against this protozoa.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenalenos / Acanthamoeba castellanii / Amebicidas Limite: Humans Idioma: En Revista: Exp Parasitol Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenalenos / Acanthamoeba castellanii / Amebicidas Limite: Humans Idioma: En Revista: Exp Parasitol Ano de publicação: 2017 Tipo de documento: Article