Mechanoregulation of clathrin-mediated endocytosis.
J Cell Sci
; 130(21): 3631-3636, 2017 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-28923837
ABSTRACT
We characterized the tension response of clathrin-mediated endocytosis by using various cell manipulation methodologies. Elevated tension in a cell hinders clathrin-mediated endocytosis through inhibition of de novo coat initiation, elongation of clathrin coat lifetimes and reduction of high-magnitude growth rates. Actin machinery supplies an inward pulling force necessary for internalization of clathrin coats under high tension. These findings suggest that the physical cues cells receive from their microenvironment are major determinants of clathrin-mediated endocytic activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinas
/
Clatrina
/
Vesículas Revestidas por Clatrina
/
Mecanotransdução Celular
/
Endocitose
/
Células Epiteliais
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Cell Sci
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos