Methylphenidate-induced information processing dysfunction in nonschizophrenic patients.
Arch Gen Psychiatry
; 45(9): 827-32, 1988 Sep.
Article
em En
| MEDLINE
| ID: mdl-2901251
ABSTRACT
To examine the relationship of aminergic overactivity to information processing, we gave methylphenidate hydrochloride, oxazepam, or placebo to 12 nonpsychotic patients in one-week blocks in a double-blind, randomized design. Methylphenidate induced a pattern of information processing dysfunction similar to that seen in schizophrenic patients, strengthening the linkage of the schizophrenia-information processing dysfunction-aminergic overactivity relationship. Further, the time course of the observed deficits in both schizophrenic and methylphenidate-induced states is strikingly compatible with the temporal mapping pattern of monoaminergic neuronal systems. More research is needed to identify definitively the aminergic influences on attentional functioning. A psychophysical task-pharmacologic probe strategy should prove useful.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atenção
/
Psicologia do Esquizofrênico
/
Percepção Visual
/
Metilfenidato
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Gen Psychiatry
Ano de publicação:
1988
Tipo de documento:
Article