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The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.
Branchford, B R; Stalker, T J; Law, L; Acevedo, G; Sather, S; Brzezinski, C; Wilson, K M; Minson, K; Lee-Sherick, A B; Davizon-Castillo, P; Ng, C; Zhang, W; Neeves, K B; Lentz, S R; Wang, X; Frye, S V; Shelton Earp, H; DeRyckere, D; Brass, L F; Graham, D K; Di Paola, J A.
Afiliação
  • Branchford BR; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Stalker TJ; University of Colorado Hemophilia and Thrombosis Center, Aurora, CO, USA.
  • Law L; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Acevedo G; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Sather S; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Brzezinski C; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Wilson KM; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Minson K; Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • Lee-Sherick AB; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Davizon-Castillo P; Department of Pediatrics, Section of Hematology/Oncology, Emory University School of Medicine, Atlanta, GA, USA.
  • Ng C; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Zhang W; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Neeves KB; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Lentz SR; University of Colorado Hemophilia and Thrombosis Center, Aurora, CO, USA.
  • Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
  • Frye SV; Department of Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, USA.
  • Shelton Earp H; Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • DeRyckere D; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
  • Brass LF; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
  • Graham DK; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
  • Di Paola JA; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
J Thromb Haemost ; 16(2): 352-363, 2018 02.
Article em En | MEDLINE | ID: mdl-29045015
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Embolia Pulmonar / Trombose / Plaquetas / Inibidores da Agregação Plaquetária / Adenina / Ativação Plaquetária / Inibidores de Proteínas Quinases / C-Mer Tirosina Quinase Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Thromb Haemost Assunto da revista: HEMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Embolia Pulmonar / Trombose / Plaquetas / Inibidores da Agregação Plaquetária / Adenina / Ativação Plaquetária / Inibidores de Proteínas Quinases / C-Mer Tirosina Quinase Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Thromb Haemost Assunto da revista: HEMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos