Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

Serbulea, Vlad; Upchurch, Clint M; Ahern, Katelyn W; Bories, Gael; Voigt, Paxton; DeWeese, Dory E; Meher, Akshaya K; Harris, Thurl E; Leitinger, Norbert

Serbulea, Vlad; Upchurch, Clint M; Ahern, Katelyn W; Bories, Gael; Voigt, Paxton; DeWeese, Dory E; Meher, Akshaya K; Harris, Thurl E; Leitinger, Norbert.

Afiliação

Serbulea V; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Upchurch CM; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Ahern KW; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22903, USA.
Bories G; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Voigt P; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
DeWeese DE; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Meher AK; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Harris TE; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22903, USA.
Leitinger N; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: nl2q@virginia.edu.

Mol Metab ; 7: 23-34, 2018 01.

Article em En | MEDLINE | ID: mdl-29153923

Assuntos

Ceramidas/metabolismo; Homeostase; Macrófagos/metabolismo; Estresse Oxidativo; Quinase Syk/metabolismo; Receptor 2 Toll-Like/metabolismo; Animais; Células Cultivadas; Glucose/metabolismo; Transportador de Glucose Tipo 1/genética; Transportador de Glucose Tipo 1/metabolismo; Glutationa/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Interleucina-1beta/genética; Interleucina-1beta/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fator 2 Relacionado a NF-E2/metabolismo; Via de Pentose Fosfato; Transdução de Sinais; Quinase Syk/genética; Receptor 2 Toll-Like/genética; Fator A de Crescimento do Endotélio Vascular/genética; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Bioenergetics; Cellular metabolism; Ceramides; Inflammation; Macrophages; Oxidized phospholipids; Redox homeostasis; Spleen tyrosine kinase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceramidas / Estresse Oxidativo / Receptor 2 Toll-Like / Quinase Syk / Homeostase / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Metab Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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