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Toward Tuberculosis Vaccine Development: Recommendations for Nonhuman Primate Study Design.
Laddy, Dominick J; Bonavia, Aurelio; Hanekom, Willem A; Kaushal, Deepak; Williams, Ann; Roederer, Mario; Seder, Robert A; Sharpe, Sally; Verreck, Frank A W; Darrah, Patricia A.
Afiliação
  • Laddy DJ; Pre-Clinical Models & Biomarker Discovery, Aeras, Rockville, Maryland, USA.
  • Bonavia A; Vir Biotechnology, San Francisco, California, USA.
  • Hanekom WA; Bill & Melinda Gates Foundation, Seattle, Washington, USA.
  • Kaushal D; Tulane National Primate Research Center, Covington, Louisiana, USA.
  • Williams A; Public Health England, Porton Down, Porton, Salisbury, United Kingdom.
  • Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Sharpe S; Public Health England, Porton Down, Porton, Salisbury, United Kingdom.
  • Verreck FAW; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
  • Darrah PA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA tdarrah@mail.nih.gov.
Infect Immun ; 86(2)2018 02.
Article em En | MEDLINE | ID: mdl-29203540
ABSTRACT
Clinical trials of novel tuberculosis (TB) vaccines are expensive, while global resources for TB vaccine development are limited. Therefore, there is a need for robust and predictive preclinical data to support advancement of candidate vaccines into clinical trials. Here, we provide a rationale for using the nonhuman primate as an essential component of these efforts, as well as guidance to the TB community for standardizing experimental design and aligning endpoints to facilitate development of new TB vaccines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Vacinas contra a Tuberculose / Modelos Animais de Doenças / Avaliação Pré-Clínica de Medicamentos Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Revista: Infect Immun Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Vacinas contra a Tuberculose / Modelos Animais de Doenças / Avaliação Pré-Clínica de Medicamentos Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Revista: Infect Immun Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos