The Power and Limitations of Influenza Virus Hemagglutinin Assays.
Biochemistry (Mosc)
; 82(11): 1234-1248, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-29223151
ABSTRACT
Influenza virus hemagglutinins (HAs) are surface proteins that bind to sialic acid residues at the host cell surface and ensure further virus internalization. Development of methods for the inhibition of these processes drives progress in the design of new antiviral drugs. The state of the isolated HA (i.e. combining tertiary structure and extent of oligomerization) is defined by multiple factors, like the HA source and purification method, posttranslational modifications, pH, etc. The HA state affects HA functional activity and significantly impacts the results of numerous HA assays. In this review, we analyze the power and limitations of currently used HA assays regarding the state of HA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Hemaglutininação de Vírus da Influenza
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Federação Russa