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Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.
Brown, Dean G; Brown, Giles A; Centrella, Paolo; Certel, Kaan; Cooke, Robert M; Cuozzo, John W; Dekker, Niek; Dumelin, Christoph E; Ferguson, Andrew; Fiez-Vandal, Cédric; Geschwindner, Stefan; Guié, Marie-Aude; Habeshian, Sevan; Keefe, Anthony D; Schlenker, Oliver; Sigel, Eric A; Snijder, Arjan; Soutter, Holly T; Sundström, Linda; Troast, Dawn M; Wiggin, Giselle; Zhang, Jing; Zhang, Ying; Clark, Matthew A.
Afiliação
  • Brown DG; 1 Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Waltham, MA, USA.
  • Brown GA; 2 Heptares Therapeutics Ltd., Welwyn Garden City, Hertfordshire, UK.
  • Centrella P; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Certel K; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Cooke RM; 5 Novartis Institute for BioMedical Research, Cambridge, MA, USA.
  • Cuozzo JW; 2 Heptares Therapeutics Ltd., Welwyn Garden City, Hertfordshire, UK.
  • Dekker N; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Dumelin CE; 4 Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Mölndal, Sweden.
  • Ferguson A; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Fiez-Vandal C; 6 Novartis Institute for BioMedical Research, Basel, Switzerland.
  • Geschwindner S; 1 Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Waltham, MA, USA.
  • Guié MA; 7 X-Chem, Inc., Waltham, MA, USA.
  • Habeshian S; 2 Heptares Therapeutics Ltd., Welwyn Garden City, Hertfordshire, UK.
  • Keefe AD; 4 Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Mölndal, Sweden.
  • Schlenker O; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Sigel EA; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Snijder A; 8 École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Soutter HT; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Sundström L; 2 Heptares Therapeutics Ltd., Welwyn Garden City, Hertfordshire, UK.
  • Troast DM; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Wiggin G; 4 Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Mölndal, Sweden.
  • Zhang J; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
  • Zhang Y; 4 Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Mölndal, Sweden.
  • Clark MA; 3 X-Chem Pharmaceuticals, Waltham, MA, USA.
SLAS Discov ; 23(5): 429-436, 2018 06.
Article em En | MEDLINE | ID: mdl-29316408
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Receptores Acoplados a Proteínas G / Bibliotecas de Moléculas Pequenas / Mutação Limite: Humans Idioma: En Revista: SLAS Discov Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Receptores Acoplados a Proteínas G / Bibliotecas de Moléculas Pequenas / Mutação Limite: Humans Idioma: En Revista: SLAS Discov Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos