Pharmacological activation of PPARÎ³ inhibits hypoxia-induced proliferation through a caveolin-1-targeted and -dependent mechanism in PASMCs.

Yang, Kai; Zhao, Mingming; Huang, Junyi; Zhang, Chenting; Zheng, Qiuyu; Chen, Yuqin; Jiang, Haiyang; Lu, Wenju; Wang, Jian

Yang, Kai; Zhao, Mingming; Huang, Junyi; Zhang, Chenting; Zheng, Qiuyu; Chen, Yuqin; Jiang, Haiyang; Lu, Wenju; Wang, Jian.

Afiliação

Yang K; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.
Zhao M; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health , Baltimore, Maryland.
Huang J; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.
Zhang C; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.
Zheng Q; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.
Chen Y; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.
Jiang H; Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine , Baltimore, Maryland.
Lu W; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.
Wang J; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China.

Am J Physiol Cell Physiol ; 314(4): C428-C438, 2018 04 01.

Article em En | MEDLINE | ID: mdl-29351409

Assuntos

Benzofenonas/farmacologia; Caveolina 1/metabolismo; Proliferação de Células/efeitos dos fármacos; Músculo Liso Vascular/efeitos dos fármacos; Miócitos de Músculo Liso/efeitos dos fármacos; PPAR gama/agonistas; Tirosina/análogos & derivados; Remodelação Vascular/efeitos dos fármacos; Animais; Apoptose/efeitos dos fármacos; Proteínas Reguladoras de Apoptose/metabolismo; Caveolina 1/genética; Proteínas de Ciclo Celular/metabolismo; Hipóxia Celular; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Células HEK293; Humanos; Masculino; Músculo Liso Vascular/metabolismo; Músculo Liso Vascular/patologia; Miócitos de Músculo Liso/metabolismo; Miócitos de Músculo Liso/patologia; PPAR gama/genética; PPAR gama/metabolismo; Artéria Pulmonar/efeitos dos fármacos; Artéria Pulmonar/metabolismo; Artéria Pulmonar/patologia; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos; Tirosina/farmacologia; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

caveolin-1; extracellular signal-regulated kinase 1/2; p38; peroxisome proliferator-activated receptor-Î³; pulmonary arterial smooth muscle cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / Benzofenonas / Miócitos de Músculo Liso / PPAR gama / Proliferação de Células / Caveolina 1 / Remodelação Vascular / Músculo Liso Vascular Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Cell Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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