Monocyte chemoattractant protein-1 (MCP-1)-2518âA/G polymorphism and lupus nephritis risk: A PRISMA-compliant meta-analysis.
Medicine (Baltimore)
; 96(51): e9401, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29390552
ABSTRACT
BACKGROUND:
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of allergic inflammatory reactions by recruiting various immune cells, which is associated with many autoimmune diseases, but the association with the MCP-1-2518A/G gene polymorphism and lupus nephritis (LN) was still controversial in previous studies. Thus, we performed a meta-analysis to derive a more precise evaluation of the association between MCP-1 -2518A/G polymorphism and LN risk and evaluated influence of ethnicity and source of controls.METHODS:
A systematic review and meta-analysis that will be performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Relevant literatures dated to September 2016 were acquired from the PubMed, EMBASE, Cochran Library databases. A total of 961 LN cases and 1867 controls were extracted from 10 published case-control studies. We used odds ratios (OR) with 95% confidence intervals (CI) to assess the risk of LN with MCP-1-2518A/G.RESULTS:
Our meta-analysis suggested that MCP-1-2518A/G polymorphism was associated with the risk of LN (GG vs AG+AA Pâ<â.01, ORâ=â1.42, 95% CI 1.13-1.79 and A vs G Pâ=â.02, ORâ=â0.74, 95% CI 0.58-0.95). Then the subgroup analysis showed MCP-1 -2518âA/G gene has a certain correlation with LN susceptibility in the American population (GG vs AA Pâ<â.01, ORâ=â5.70, 95% CI 2.09-15.50, GG vs AG+AA Pâ<â.01, ORâ=â3.31, 95% CI 1.97-5.54, GG+AG vs AA Pâ<â.01, ORâ=â2.86, 95% CI 1.14-7.18, and A vs G Pâ<â.01, ORâ=â0.43, 95% CI 0.24-0.79), while no significant risk in Europeans and Asians.CONCLUSION:
The current meta-analysis suggests that the MCP-1-2518A/G polymorphism is associated with an increased risk of LN, especially in the American population. However, better-designed studies with larger sample sizes are needed to validate the results.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nefrite Lúpica
/
Quimiocina CCL2
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Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China