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[Autograft of bone marrow treated by in vitro chemotherapy (Asta Z 7557) for consolidation of acute leukemia in adults in the first complete remission]. / Autogreffe de moelle osseuse traitée par chimiothérapie in vitro (Asta Z 7557) en consolidation des leucémies aiguës de l'adulte en première rémission complète.
Presse Med ; 16(7): 338-42, 1987 Feb 28.
Article em Fr | MEDLINE | ID: mdl-2950482
ABSTRACT
Fourteen adult patients in first complete remission of acute leukemia (A.L.) [6 with acute lymphoblastic leukemia (ALL), 8 with acute non lymphoblastic leukemia (ANLL)] were consolidated with high dose cyclophosphamide and total body irradiation followed by autologous bone marrow transplantation (ABMT) with marrow cleansed in vitro by Asta Z 7557. According to our previously described protocol showing evidence for a wide range of sensitivity from patient to patient, the marrow of each individual patient was incubated with the highest tolerable dose of Asta Z 7557. This dose, individually determined, was defined as the dose sparing between 0 and 10% of CFU-GM (CFU-GM DL95). ABMT was not followed by maintenance therapy. Hematological reconstitution was significantly faster in ALL patients when compared to ANLL patients. Out of these 14 patients 2 relapsed on months 5 and 15 respectively after ABMT, and 2 died in complete remission on months 3 and 16 respectively, of veno-occlusive disease and encephalitis. Ten patients (70%) remain in complete remission up to a median of 15 months +, with 4 patients over 24 months +.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Transplante de Medula Óssea / Ciclofosfamida Tipo de estudo: Guideline Limite: Adult / Female / Humans / Male / Middle aged Idioma: Fr Revista: Presse Med Ano de publicação: 1987 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Transplante de Medula Óssea / Ciclofosfamida Tipo de estudo: Guideline Limite: Adult / Female / Humans / Male / Middle aged Idioma: Fr Revista: Presse Med Ano de publicação: 1987 Tipo de documento: Article