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Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Nelp, Micah T; Kates, Patrick A; Hunt, John T; Newitt, John A; Balog, Aaron; Maley, Derrick; Zhu, Xiao; Abell, Lynn; Allentoff, Alban; Borzilleri, Robert; Lewis, Hal A; Lin, Zeyu; Seitz, Steven P; Yan, Chunhong; Groves, John T.
Afiliação
  • Nelp MT; Department of Chemistry, Princeton University, Princeton, NJ 08544.
  • Kates PA; Department of Chemistry, Princeton University, Princeton, NJ 08544.
  • Hunt JT; Immuno-oncology Biology, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Newitt JA; Molecular Discovery Technologies, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Balog A; Department of Discovery Chemistry, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Maley D; Immuno-oncology Biology, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Zhu X; Molecular Discovery Technologies, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Abell L; Leads Discovery and Optimization, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Allentoff A; Department of Radiochemistry, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Borzilleri R; Department of Discovery Chemistry, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Lewis HA; Molecular Discovery Technologies, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Lin Z; Leads Discovery and Optimization, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Seitz SP; Department of Discovery Chemistry, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Yan C; Molecular Discovery Technologies, Bristol-Myers Squibb Co., Princeton, NJ 08543.
  • Groves JT; Department of Chemistry, Princeton University, Princeton, NJ 08544; jtgroves@princeton.edu.
Proc Natl Acad Sci U S A ; 115(13): 3249-3254, 2018 03 27.
Article em En | MEDLINE | ID: mdl-29531094
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article