A guide to integrating immunohistochemistry and chemical imaging.
Chem Soc Rev
; 47(11): 3770-3787, 2018 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-29542747
ABSTRACT
Chemical imaging provides new insight into the fundamental atomic, molecular, and biochemical composition of tissue and how they are interrelated in normal physiology. Visualising and quantifying products of pathogenic reactions long before structural changes become apparent also adds a new dimension to understanding disease pathogenesis. While chemical imaging in isolation is somewhat limited by the nature of information it can provide (e.g. peptides, metals, lipids, or functional groups), integrating immunohistochemistry allows simultaneous, targeted imaging of biomolecules while also mapping tissue composition. Together, this approach can provide invaluable information on the inner workings of the cell and the molecular basis of diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Imuno-Histoquímica
/
Imagem Molecular
/
Lipídeos
/
Metais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Soc Rev
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália