Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals.
J Bone Jt Infect
; 3(1): 10-14, 2018.
Article
em En
| MEDLINE
| ID: mdl-29545990
ABSTRACT
Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Bone Jt Infect
Ano de publicação:
2018
Tipo de documento:
Article