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Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.
Kapojos, Magie M; Abdjul, Delfly B; Yamazaki, Hiroyuki; Ohshiro, Taichi; Rotinsulu, Henki; Wewengkang, Defny S; Sumilat, Deiske A; Tomoda, Hiroshi; Namikoshi, Michio; Uchida, Ryuji.
Afiliação
  • Kapojos MM; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan; Faculty of Nursing, University of Pembangunan Indonesia, Bahu, Manado 95115, Indonesia.
  • Abdjul DB; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan; North Sulawesi Research and Development Agency, 17 Agustus Street, Manado 95117, Indonesia; Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115,
  • Yamazaki H; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan. Electronic address: yamazaki@tohoku-mpu.ac.jp.
  • Ohshiro T; Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan.
  • Rotinsulu H; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan; Faculty of Mathematic and Natural Sciences, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia.
  • Wewengkang DS; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan; Faculty of Mathematic and Natural Sciences, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia.
  • Sumilat DA; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan; Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia.
  • Tomoda H; Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan.
  • Namikoshi M; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan.
  • Uchida R; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan. Electronic address: uchidar@tohoku-mpu.ac.jp.
Bioorg Med Chem Lett ; 28(10): 1911-1914, 2018 06 01.
Article em En | MEDLINE | ID: mdl-29631961
ABSTRACT
Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data. Compounds 1-3 inhibited both of the SOAT isozymes, SOAT1 and SOAT2, in cell-based and enzyme-based assays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esterol O-Aciltransferase / Callyspongia / Dipeptídeos / Inibidores Enzimáticos Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Indonésia
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esterol O-Aciltransferase / Callyspongia / Dipeptídeos / Inibidores Enzimáticos Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Indonésia