Albumin levels and cause-specific mortality in community-dwelling older adults.
Prev Med
; 112: 145-151, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29649489
ABSTRACT
To investigate the association between serum albumin levels and cause-specific mortality among community-dwelling older adults. This cohort study was based on data obtained from the government-sponsored Annual Geriatric Health Examination Program for the older adults in Taipei City between 2006 and 2010. The study sample consisted of 77,531 community-dwelling Taipei citizens (≥65â¯years old). Mortality was determined by matching the participants' medical records with national death files. Serum albumin levels were categorized into <3.6, 3.6-3.7, 3.8-3.9, 4.0-4.1, 4.2-4.3, and ≥4.4â¯g/dL. Cox proportional hazards regression models were used to evaluate the association between albumin levels and cause-specific mortality. Spline regression was used to calculate the risk of mortality associated with albumin levels, modeled as continuous variables. Community-dwelling older adults had a mean albumin level of 4.3â¯g/dL, which significantly reduced by age. Compared to albumin levels ≥4.4â¯g/dL, mildly low albumin levels (4.2-4.3â¯g/dL) were associated with an increased mortality risk (hazard ratio [HR] 1.16, 95% confidence interval [CI] 1.05-1.28 for all-cause mortality), and albumin levels <4.2â¯g/dL were associated with significantly higher rates of all-cause, cancer, cardiovascular, and respiratory mortalities. In the spline regression, the curve of mortality risk was relatively flat at an albumin level ≥4.4â¯g/dL, and the mortality risk gradually increased as the albumin level declined. Albumin levels ≥4.4â¯g/dL were associated with better survival among community-dwelling older adults, and mortality risk increased as the albumin level decreased.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Causas de Morte
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Vida Independente
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Albumina Sérica Humana
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Neoplasias
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Prev Med
Ano de publicação:
2018
Tipo de documento:
Article