Characterization of a novel allelic variant in HLA-B*40 lineage, HLA-B*40:298:02, by cloning and sequencing.
Int J Immunogenet
; 45(3): 143-145, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29676515
ABSTRACT
A novel allelic variant in HLA-B*40 lineage, HLA-B*4029802, has been identified in an individual of Han ethnicity afflicted with nasopharyngeal carcinoma in Hunan province, southern China. Following polymerase chain reaction-Sanger sequence-based typing (PCR-SBT), this new variant was further confirmed by two distinct strategies of cloning and sequencing. HLA-B*4029802 differs from HLA-B*4029801 by a single synonymous cytosine substitution at nucleotide position 26 (TâC) in exon 3, which corresponds to codon 99 of the mature HLA-B mRNA molecule. This new allele has an estimated frequency of 0.0002, in about 2,500 sequence-based typed subjects from the same population.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Antígenos HLA-B
/
Alelos
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Immunogenet
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
GENETICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China