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2-Methyl-versiquinazoline C, a new fumiquinazoline-type alkaloid from the fungus Aspergillus flavipes PJ03-11.
Si, Ying-Ying; Tang, Ming-Xu; Lin, Shuang; Chen, Gang; Hua, Hui-Ming; Bai, Jiao; Wang, Yu-Bo; Wang, Hai-Feng; Pei, Yue-Hu.
Afiliação
  • Si YY; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Tang MX; b Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016 , China.
  • Lin S; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Chen G; b Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016 , China.
  • Hua HM; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Bai J; b Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016 , China.
  • Wang YB; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Wang HF; b Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016 , China.
  • Pei YH; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
J Asian Nat Prod Res ; 21(6): 528-534, 2019 Jun.
Article em En | MEDLINE | ID: mdl-29693414
ABSTRACT
A new fumiquinazoline-type alkaloid 2-methyl-versiquinazoline C (1), together with six known compounds (2-7), was isolated from Aspergillus flavipes PJ03-11 using OSMAC method. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound 1 was determined by the experimental and calculated ECD data. In addition, the cytotoxic activities against three human cancer cell lines (HL-60, THP-1, and PC-3) were evaluated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Aspergillus / Alcaloides / Antibióticos Antineoplásicos Limite: Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Aspergillus / Alcaloides / Antibióticos Antineoplásicos Limite: Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China