Mucin expression profile of benign and malignant cervical tissues and correlation with clinical-pathologic parameters.
Eur J Gynaecol Oncol
; 38(3): 350-355, 2017.
Article
em En
| MEDLINE
| ID: mdl-29693871
ABSTRACT
PURPOSE:
To detect the expression of mucins in diverse benign and malignant cervical tissues of cervical disease. MATERIALS ANDMETHODS:
158 cases of cervical tissues were collected. Sections were stained with monoclonal antibodies against MUC1, MUC2, MIUC4, MUC5AC, and MUC20 by immunohistochemistry.RESULTS:
Normal cervical epithelium showed high expr ession of MUC1I, MUC4, and MUC5AC, partial expression of MUC20, and no MUC2. With the development from chronic cervicitis, cervical intraepithelial neoplasia (CI7N) to cervical squamous cell carcinoma (SCC), the expression of MUC1, NMUC4, and MUC20 was statistically significant. The expression of MUCl was related with the depth of invasion and clinical stage of SCC. The positive rates of MUC4 and MUC20 were associated with the degree of differentiation and clinical stage of SCC. There was a correlation between the expression of MUC4, MUC 1, and MUC20 in cervical squamous lesions.CONCLUSION:
Mucins may be involved in the development of cervical cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Displasia do Colo do Útero
/
Neoplasias do Colo do Útero
/
Mucinas
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Ano de publicação:
2017
Tipo de documento:
Article