[Perioperative factors influencing the tolerability of chemotherapy after lung lobe resection]. / Tüdolebeny-eltávolítást követo kemoterápia tolerabilitását befolyásoló perioperatív tényezok.
Orv Hetil
; 159(19): 748-755, 2018 May.
Article
em Hu
| MEDLINE
| ID: mdl-29730942
ABSTRACT
INTRODUCTION:
Lung cancer is the leading cause of malignancy-related deaths in Hungary, involving complex surgical and oncological treatment.AIM:
Factors influencing the tolerability of complete/planned and incomplete postoperative chemotherapy after surgery were analyzed.METHOD:
During a 6-year period (January 1, 2011-December 31, 2016), data of 72 patients operated with lung cancer (adenocarcinoma and squamous cell carcinoma), receiving complete (4 cycles) and incomplete (<4 cycles) postoperative chemotherapy were analyzed. The following factors among the two groups [complete n = 53; incomplete n = 19] were analyzed gender, mean age, body mass index, Malnutrition Universal Screening Tool, Charlson Comorbidity Index, second malignant tumor, atrial fibrillation, Forced Expiratory Volume 1 sec, Performance Status, open/Video-Assisted Thoracic Surgery (VATS) lobectomy, duration of surgery, postoperative fever, need for transfusion, prolonged air leak, redo surgery, histology, tumor stage.RESULTS:
The rate of complete postoperative cycles obtained from logistic regression analysis, were substantially higher after VATS lobectomies [n = 26 (83.87%)] compared to open procedures [n = 27 (65.85%)]; (p = 0.092; OR = 0.356), without significance. Multivariate analysis (open/VATS lobectomy, upper/middle-lower lobe resection, diabetes, prolonged air leak, postoperative fever) showed significantly increased successful uptake of complete cycles after VATS (p = 0.0495), while upper/middle lobe resections (p = 0.0678) and the lack of diabetes (p = 0.0971) notably increased the number of complete cycles, without significance.CONCLUSION:
Twenty-six percent of patients were unable to receive complete planned postoperative chemotherapy. VATS lobectomy patients received significantly higher number of complete cycles of postoperative chemotherapy. Diabetes and lower lobe lobectomies had a negative effect on the tolerability of postoperative chemotherapy. Orv Hetil. 2018; 159(19) 748-755.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Adenocarcinoma
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Protocolos de Quimioterapia Combinada Antineoplásica
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Carcinoma Pulmonar de Células não Pequenas
Limite:
Female
/
Humans
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Male
País/Região como assunto:
Europa
Idioma:
Hu
Revista:
Orv Hetil
Ano de publicação:
2018
Tipo de documento:
Article